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Explore Blood Group Systems

Discover all 44 officially recognized blood group systems and the hundreds of antigens that make each one unique. Data sourced in real-time from the ISBT Blood Group Database.

Why This Matters

Beyond ABO and Rh, these blood group systems become critical for patients who receive multiple transfusions, pregnant women, and anyone who develops antibodies to other blood group antigens.

Multiple Systems

Each blood group system is defined by a gene or gene complex that produces specific antigens on red blood cells.

Clinical Significance

Some antigens are highly immunogenic and can cause transfusion reactions or hemolytic disease of the newborn.

Genetic Diversity

Antigen frequencies vary by population, making blood donor diversity essential for finding compatible blood.

Explore Blood Group Systems

Click any system to see its antigens. Data from the ISBT Blood Group Database.

Discovery years are approximate based on historical literature. Data source: ISBT Blood Group Database

ABO
System 1
1900
ABO4 antigens
ABO
MNS
System 2
1927
MNS50 antigens
GYPA, GYPB, GYPE
P1PK
System 3
1927
P1PK3 antigens
A4GALT
Rh
System 4
1940
RH56 antigens
RHD, RHCE
Lutheran
System 5
1945
LU29 antigens
BCAM
Kell
System 6
1946
KEL38 antigens
KEL
Lewis
System 7
1946
LE6 antigens
FUT3
Duffy
System 8
1950
FY5 antigens
ACKR1
Kidd
System 9
1951
JK3 antigens
SLC14A1
Diego
System 10
DI23 antigens
SLC4A1
Yt
System 11
YT6 antigens
ACHE
Xg
System 12
XG2 antigens
XG
Scianna
System 13
SC11 antigens
ERMAP
Dombrock
System 14
DO10 antigens
ART4
Colton
System 15
CO4 antigens
AQP1
Landsteiner-Wiener
System 16
LW4 antigens
ICAM4
Chido/Rodgers
System 17
CH_RG9 antigens
H
System 18
H1 antigen
FUT1
Kx
System 19
XK1 antigen
XK
Gerbich
System 20
GE13 antigens
Cromer
System 21
CROM21 antigens
Knops
System 22
KN14 antigens
CR1
Indian
System 23
IN6 antigens
CD44
Ok
System 24
OK3 antigens
BSG
Raph
System 25
RAPH1 antigen
CD151
John Milton Hagen
System 26
JMH8 antigens
SEMA7A
I
System 27
I1 antigen
GCNT2
Globoside
System 28
GLOB3 antigens
B3GALNT1
Gill
System 29
GIL1 antigen
AQP3
Rh-associated glycoprotein
System 30
RHAG6 antigens
RHAG
FORS
System 31
FORS1 antigen
GBGT1
JR
System 32
JR1 antigen
ABCG2
LAN
System 33
LAN1 antigen
ABCB6
Vel
System 34
VEL1 antigen
SMIM1
CD59
System 35
CD591 antigen
CD59
Augustine
System 36
AUG4 antigens
SLC29A1
Kanno
System 37
KANNO1 antigen
PRNP
SID
System 38
SID1 antigen
B4GALNT2
CTL2
System 39
CTL25 antigens
SLC44A2
PEL
System 40
PEL1 antigen
ABCC4
MAM
System 41
MAM1 antigen
EMP3
EMM
System 42
EMM1 antigen
PIGG
ABCC1
System 43
ABCC11 antigen
ABCC1
Er
System 44
ER5 antigens

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